pH-Dependent Conformational Changes in Proteins and their Effect on Experimental pKas: The Case of Nitrophorin 4 2) Authors
نویسندگان
چکیده
3) Affiliations ≠ Quantum Theory Project and Department of Chemistry, University of Florida, Gainesville, Florida 32611-8435 USA; § Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE-CONICET. Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires. Ciudad Universitaria, Pab. 2, C1428EHA, Buenos Aires, Argentina. ¶ Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires. Ciudad Universitaria, Pab. 2, C1428EHA, Buenos Aires, Argentina. *E-mail: [email protected], [email protected]
منابع مشابه
pH-Dependent Conformational Changes in Proteins and Their Effect on Experimental pKas: The Case of Nitrophorin 4
The acid-base behavior of amino acids is an important subject of study due to their prominent role in enzyme catalysis, substrate binding and protein structure. Due to interactions with the protein environment, their pK(a)s can be shifted from their solution values and, if a protein has two stable conformations, it is possible for a residue to have different "microscopic", conformation-dependen...
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